Abstract: Based on observation data, the correlation analysis of the Tibetan Plateau thermal condition and Meiyu in the Yangtze River Basin is conducted. The statistic results indicate that the surface thermal condition is correlated with the flood/drought in the Yangtze River Basin. If there exists abnormally warm thermal condition over the southern Tibet, then there will be a flooding summer in the Yangtze River Basin and vice versa. Based on such results, two sensitive experiments are designed by use of the NCAR RegCM2 model, in which the ground temperature of the northern or southern Tibetan Plateau increases or decreases respectively. The experiments simulated the features very well and validated the statistic results.