Abstract: Meso-scale meteorology has been the primary research area of Chinese Academy of Meteorological Sciences for the recent 50 years. As early as in 1963, Chinese Academy of Meteorological Sciences is already a dominant participator of the first Yangtze Area Delta Meso-scale Meteorology Field Experiment. Since then, a series of grand science research programs are directed, among which are Monitoring and Ultra-short Term Predicting of Disaster Weather in Beijing, Tianjin and Hebei District during 1986—1990, Torrential Rainfall Experiment over Both Side of the Taiwan Strait and Adjacent Area (HUAMEX) during 1997—2003, Research on Formation Mechanism and Prediction Theory of Severe Weather Disasters in China during 1998—2003, Research on Theories and Methods of Monitoring and Predicting of Heavy Rainfall in South China during 2004—2009. In these programs, Chinese Academy of Meteorological Sciences successfully develops lots of innovative instruments, e.g., digital weather radar systems, Doppler weather radar systems, mounted Doppler weather radar systems, wind profiles radar systems, double channel auto-scanning microwave radiometers, automatic weather station network and an effective integrated system of meso-scale meteorological data collecting, processing, analyzing and displaying. A nonhydrostatic multi-scale atmospherical numerical forecasting model has also been developed. With the implementation of modern meso-scale observation network, Chinese Academy of Meteorological Sciences starts several meso-scale storms observation experiments, and obtains plentiful data. Very important scientific and technological support to research of meso-scale meteorology in China have been provided by these approaches. Thanks to these contributions, Chinese Academy of Meteorological Sciences has received 16 National Awards of Scientific and Technological Progress.