Abstract: Necessity for developing of ocean-meteorological navigation, and its principle and impact factors of the route choice are described. With the operation of route choice in recent 10 years at the Center of Ocean-Meteorological Route in the Central Meteorological Observatory, the impact factors of climate over North Indian Ocean on route choice in winter and summer are summarized. It is shown that different meteorological routes should be chosen in combining with winter and summer climate variation over North Indian Ocean and characteristics of ocean orography. This work supplies a valuable basis in the operation for choosing different favorable routes avoiding high frequency regions with strong wind and huge wave according to the conditions of different seasons and ships