Abstract: By contrasting the data of the digestive ulcer cases from 1984 to 1993 with the corresponding meteorological data in Beijing area, the seasonal and annual variations of detective rate of the cases are revealed. The meteorological conditions in which this illness occurs more frequently for different seasons are also discussed. On this basis, the predictive models of detective rate of digestive ulcer cases for winter, autumn and summer are designed by using the optimal subset regression method.